It's important to note, however, that these benefits are often seen with the type of CLA found in food, not supplements. Necessary cookies are absolutely essential for the website to function properly. Potential Side Effects of Conjugated Linoleic Acid (CLA) CLA supplements may cause nervous stomach, nausea, the runs, and weariness. Conjugated Linoleic Acid, or CLA for short, is a fatty acid that has taken the supplement world by storm. These may indicate that you should stop taking the supplement. But many of these early studies were done on animals, and when the same experiments were tried on people, the results weren't anywhere near as favorable. Conjugated linoleic acid may be able to reduce body fat and prevent cancer by affecting certain body cells. Conjugated linoleic acid (CLA) is a fatty acid that is naturally found in meat and dairy products. Taking a CLA supplement along with an anticoagulant ("blood thinners") or nonsteroidal anti-inflammatory drug (NSAID) can further enhance this effecting, leading to easy bruising and bleeding.14 Possible drug interactions include: 1. This insulin resistance can raise the level of blood sugar, causing hyperglycemia. Scientists have shown that 3,000 milligrams, or three grams, is the minimum recommendation for fat reduction. Our site includes quite a bit of content, so if you're having an issue finding what you're looking for, go on ahead and use that search feature there! Conjugated linoleic acid is claimed to be beneficial for us in several ways. Chemically, it is an isomer of an essential, unsaturated, and omega 6 fatty acid, known as linoleic acid. However, some human studies using reasonable doses indicate that CLA supplements may cause several mild or moderate side effects, including diarrhea, insulin resistance and oxidative stress … Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. There are several side effects associated with conjugated linoleic acid. ” Am J Clin Nutr. Trans-10, cis-12 is the form most often found in supplements. ” Int J Obes (Lond). This website uses cookies to improve your experience while you navigate through the website. Large doses can also trigger the accumulation of fat in the liver, leading to fatty liver disease, diabetes, and metabolic syndrome. Since various formulations contain different amounts of CLA, it's wise to take a pure CLA supplement or make sure you're getting the right levels from combination supplements. Cows and other cud-chewing animals such as sheep, goats, and deer have a special bacteria in their stomachs that convert linoleic acid (a type of fatty acid) into CLA. The scientists reported that on average, the people who supplemented with CLA lost more fat than those not taking CLA, but the amount averaged less than a quarter of a pound per week., Based on the current evidence at the time, a 2015 review published in Nutrition and Metabolism concluded that CLA offered no "promising or consistent health effects so as to uphold it as either a functional or medical food. Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. Published 2015 Sep 17. doi:10.1186/s12970-015-0097-4, Chen SC, Lin YH, Huang HP, Hsu WL, Houng JY, Huang CK. On rare occasion, CLA may cause liver toxicity (usually in people with underlying liver disease). Effect of conjugated linoleic acid supplementation on weight loss and body fat composition in a Chinese population. J Strength Cond Res. As for other effects on heart health, the 2015 review study found that a host of both beneficial and detrimental effects of CLA were observed during clinical studies. 2007 May;85(5):1203-11 Watras AC, Buchholz AC, Close RN, Zhang Z, Schoeller DA. 2007;85(5):1203-11. doi:10.1093/ajcn/85.5.1203, Benjamin S, Prakasan P, Sreedharan S, Wright AD, Spener F. Pros and cons of CLA consumption: an insight from clinical evidences. Updated. People taking a CLA supplement saw a decrease in body fat that was less than a half percentage point lower than those not taking the pill., A 2015 review study showed mixed results. In another report from 2007, researchers evaluated the results from 18 studies where participants took the supplement for a longer period of time (six months to two years). Some forms of CLAs make the body resistant to insulin. We therefore studied the effect of a high daily intake of CLA on liver and kidney function in healthy subjects. CLA has been demonstrated to be an efficient, potent and convenient fat loss and bodybuilding supplement. 2012;26(6):1667-74. doi:10.1519/JSC.0b013e318231ab78, Jenkins ND, Buckner SL, Baker RB, et al. Potentially serious and should be reported to your healthcare provider level of the inflammatory protein, can... To 6 grams per day. describes the safety and effectiveness of conjugated linoleic acid this acid signals body! Primarily found in meat and dairy products adverse effect on your website is a nutritional supplement often used body. Potentially serious and should be reported to your healthcare provider accumulation of in! Hepatomegaly in animals, but you can opt-out if you wish, it does not have much effect on browsing! The body meat ( grass-fed animals may have higher levels ) and dairy products prevent by... 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